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Do not expose to repeated freezethaw cycles

Semaglutide treatment affects many of these domains simultaneously, making it challenging to isolate specific causative mechanisms

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[55] reported that semaglutide treatment caused weight loss and a lesser decrease in energy expenditure as compared with placebo in calorie-restricted, weight-matched rodents

Esterbauer H, Rotheneder M, Striegel G, Waeg G, Ashy A, Sattler W, Jurgens G